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Suzuki et al, Development.pdf466KbAdobe PDF見る/開く
タイトル :Regulation of outgrowth and apoptosis for the terminal appendage: external genitalia: development by concerted actions of BMP signaling
著者 :Suzuki, Kentaro
Daniel, Bachiller
Chen, YiPing P.
Kamikawa, Mami
Ogi, Hidenao
Haraguchi, Ryuma
Ogino, Yukiko
Minami, Yasuhiro
Mishina, Yuji
Ahn, Kyung
Crenshaw III, E. Bryan
Yamada, Gen
刊行年月日 :2003-12
収録雑誌名 :Development
巻 :130
号 :25
開始ページ :6209
終了ページ :6220
要約(Abstract) :Extra-corporal fertilization depends on the formation of copulatory organs: the external genitalia. Coordinated growth and differentiation of the genital tubercle (GT), an embryonic anlage of external genitalia, generates a proximodistally elongated structure suitable for copulation, erection, uresis and ejaculation. Despite recent progress in molecular embryology, few attempts have been made to elucidate the molecular developmental processes of external genitalia formation. Bone morphogenetic protein genes (Bmp genes) and their antagonists were spatiotemporally expressed during GT development. Exogenously applied BMP increased apoptosis of GT and inhibited its outgrowth. It has been shown that the distal urethral epithelium (DUE), distal epithelia marked by the Fgf8 expression, may control the initial GT outgrowth. Exogenously applied BMP4 downregulated the expression of Fgf8 and Wnt5a, concomitant with increased apoptosis and decreased cell proliferation of the GT mesenchyme. Furthermore, noggin mutants and Bmpr1a conditional mutant mice displayed hypoplasia and hyperplasia of the external genitalia respectively. noggin mutant mice exhibited downregulation of Wnt5a and Fgf8 expression with decreased cell proliferation. Consistent with such findings, Wnt5a mutant mice displayed GT agenesis with decreased cell proliferation. By contrast, Bmpr1a mutant mice displayed decreased apoptosis and augmented Fgf8 expression in the DUE associated with GT hyperplasia. These results suggest that some of the Bmp genes could negatively affect proximodistally oriented outgrowth of GT with regulatory functions on cell proliferation and apoptosis. The DUE region can be marked only until 14.0 dpc (days post coitum) in mouse development, while GT outgrowth continues thereafter. Possible signaling crosstalk among the whole distal GT regions were also investigated.
URL :http://dev.biologists.org/cgi/content/full/130/25/6209
収録種別 :雑誌掲載論文
出版社(者) :Company of Biologists
URI :http://hdl.handle.net/2298/10389
このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/2298/10389