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Journal Article( Institute of Resource Development and Genetics) >
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| Title | : | Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling |
| Authors | : | Haraguchi, Ryuma
Motoyama, Jun
Sasaki, Hiroshi
Satoh, Yoshihiko
Miyagawa, Shinichi
Nakagata, Naomi
Moon, Anne
Yamada, Gen |
| Issue Date | : | Feb-2007 |
| Citation jtitle | : | Development |
| vol. | : | 134 |
| no. | : | 3 |
| start page | : | 525 |
| end page | : | 533 |
| Abstract | : | The urogenital and reproductive organs, including the external genitalia, bladder and urethra, develop as anatomically aligned
organs. Descriptive and experimental embryology suggest that the cloaca, and its derivative, the urogenital sinus, contribute to the
formation of these organs. However, it is unknown how the primary tissue lineages in, and adjacent to, the cloaca give rise to the
above organs, nor is bladder formation understood. While it is known that sonic hedgehog (Shh) is expressed by the cloacal
epithelia, the developmental programs that regulate and coordinate the formation of the urogenital and reproductive organs have
not been elucidated. Here we report that Shh mutant embryos display hypoplasia of external genitalia, internal urethra (pelvic
urethra) and bladder. The importance of Shh signaling in the development of bladder and external genitalia was confirmed by
analyzing a variety of mutant mouse lines with defective hedgehog signaling. By genetically labeling hedgehog-responding tissue
lineages adjacent to the cloaca and urogenital sinus, we defined the contribution of these tissues to the bladder and external
genitalia. We discovered that development of smooth muscle myosin-positive embryonic bladder mesenchyme requires Shh
signaling, and that the bladder mesenchyme and dorsal (upper) external genitalia derive from Shh-responsive peri-cloacal
mesenchyme. Thus, the mesenchymal precursors for multiple urogenital structures derive from peri-cloacal mesenchyme and the
coordination of urogenital organ formation from these precursors is orchestrated by Shh signals. |
| URL | : | http://dev.biologists.org/cgi/content/full/134/3/525 |
| Type Local | : | 雑誌掲載論文 |
| Publisher | : | Company of Biologists |
| URI | : | http://hdl.handle.net/2298/10390 |
| Appears in Collections | : | Journal Article( Institute of Resource Development and Genetics)
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2298/10390
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