HOME   English    

Kumamoto University Repository System >
センター等 >
エイズ学研究センター >
発表論文(エイズ研) >



ファイル 記述 サイズフォーマット
Okada et al.pdf511KbAdobe PDF見る/開く
タイトル :Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells
著者 :Okada, Seiji
Harada, Hideki
Ito, Takaaki
Saito, Takashi
Suzu, Shinya
刊行年月日 :2008-12
収録雑誌名 :International Journal of Hematology
巻 :88
号 :5
開始ページ :476
終了ページ :482
要約(Abstract) :An animal model in which the human immune system can be reconstituted is necessary to study acquired immunity in vivo. We report here a novel model, the NOD/SCID/JAK3null mouse, for the human immune system's development. Newborn mice transplanted with human cord blood CD34+ cells intrahepatically, developed human T and B cells, and myeloid and plasmacytoid dendritic cells. The T and B cells had a naïve to memory phenotype, and included plasma cells. The human acquired immune system can be reconstituted from CD34+ cells in NOD/SCID/JAK3null mice. This model is a powerful tool for the study of human immunity.
URL :http://www.jshem.or.jp/journal/
収録種別 :雑誌掲載論文
出版社(者) :日本血液学会
権利(Rights) :© 2008 The Japanese Society of Hematology.
URI :http://hdl.handle.net/2298/10909
このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/2298/10909