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Title :Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells
Authors :Okada, Seiji
Harada, Hideki
Ito, Takaaki
Saito, Takashi
Suzu, Shinya
Issue Date :Dec-2008
Citation jtitle :International Journal of Hematology
vol. :88
no. :5
start page :476
end page :482
Abstract :An animal model in which the human immune system can be reconstituted is necessary to study acquired immunity in vivo. We report here a novel model, the NOD/SCID/JAK3null mouse, for the human immune system's development. Newborn mice transplanted with human cord blood CD34+ cells intrahepatically, developed human T and B cells, and myeloid and plasmacytoid dendritic cells. The T and B cells had a naïve to memory phenotype, and included plasma cells. The human acquired immune system can be reconstituted from CD34+ cells in NOD/SCID/JAK3null mice. This model is a powerful tool for the study of human immunity.
URL :http://www.jshem.or.jp/journal/
Type Local :雑誌掲載論文
Publisher :日本血液学会
Rights :© 2008 The Japanese Society of Hematology.
URI :http://hdl.handle.net/2298/10909
Appears in Collections:Journal Article (Center for AIDS Research)
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/10909