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Title :Expression patterns of epiplakin1 in pancreas,pancreatic cancer and regenerating pancreas
Authors :Yoshida, Tetsu
Shiraki, Nobuaki
Baba, Hideo
Goto, Mizuki
Fujiwara, Sakuhei
Kume, Kazuhiko
Kume, Shoen
Issue Date :Jul-2008
Citation jtitle :Genes to cells
vol. :13
no. :7
start page :667
end page :678
Abstract :Epiplakin1 (Eppk1) is a plakin family gene with its function remains largely unknown, although the plakin genes are known to function in interconnecting cytoskeletal filaments and anchoring them at plasma membrane-associated adhesive junction. Here we analyzed the expression patterns of Eppk1 in the developing and adult pancreas in the mice. In the embryonic pancreas, Eppk1+/Pdx1+ and Eppk1+/Sox9+ pancreatic progenitor cells were observed in early pancreatic epithelium. Since Pdx1 expression overlapped with that of Sox9 at this stage, these multipotent progenitor cells are Eppk1+/Pdx1+/Sox9+ cells. Then Eppk1 expression becomes confined to Ngn3+ or Sox9+ endocrine progenitor cells, and p48+ exocrine progenitor cells, and then restricted to the duct cells and a cells at birth. In the adult pancreas, Eppk1 is expressed in centroacinar cells (CACs) and in duct cells. Eppk1 is observed in pancreatic intraepithelial neoplasia (PanIN), previously identified as pancreatic ductal adenocarcinoma (PDAC) precursor lesions. In addition, the expansion of Eppk1-positive cells occurs in a caerulein-induced acute pancreatitis, an acinar cell regeneration model. Furthermore, in the partial pancreatectomy (Px) regeneration model using mice, Eppk1 is expressed in "ducts in foci", a tubular structure transiently induced. These results suggest that Eppk1 serves as a useful marker for detecting pancreatic progenitor cells in developing and regenerating pancreas.
Type Local :雑誌掲載論文
Publisher :Blackwell Publishing
Rights :©2008 by the Molecular Biology Society of Japan/Blackwell Publishing
URI :http://hdl.handle.net/2298/11001
Relation :http://www3.interscience.wiley.com/journal/118514823/home
Appears in Collections:Journal Article (Institute of Molecular Embryology and Genetics)
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/11001