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Title :Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal death
Authors :Yamada, Gen
Mansouri, Ahmed
Torres, Miguel
Stuart, Edward T.
Blum, Martin
Schultz, M.
De Robertis, Eddy M.
Gruss, Peter
Issue Date :1995
Citation jtitle :Development
vol. :121
start page :2917
end page :2922
Abstract :The goosecoid gene encodes a homeodomain-containing protein that has been identified in a number of species and has been implicated in a variety of key developmental processes. Initially suggested to be involved in organizing the embryo during early development, goosecoid has since been demonstrated to be expressed during organogenesis – most notably in the head, the limbs and the ventrolateral body wall. To investigate the role of goosecoid in embryonic development, we have inactivated the gene by gene targeting to generate mice mutant for the goosecoid gene. Mice that are homozygous for the goosecoid mutation do not display a gastrulation phenotype and are born; however, they do not survive more than 24 hours. Analysis of the homozygotes revealed numerous developmental defects affecting those structures in which goosecoid is expressed during its second (late) phase of embryonic expression. Predominantly, these defects involve the lower mandible and its associated musculature including the tongue, the nasal cavity and the nasal pits, as well as the components of the inner ear (malleus, tympanic ring) and the external auditory meatus. Although the observed phenotype is in accordance with the late expression domains of goosecoid in wild-type embryos, we suggest that the lack of an earlier phenotype is the result of functional compensation by other genes.
URL :http://dev.biologists.org/cgi/content/abstract/121/9/2917
Type Local :雑誌掲載論文
Publisher :Company of Biologists
URI :http://hdl.handle.net/2298/13369
Appears in Collections:Journal Article (Institute of Resource Development and Genetics)
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/13369