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Title :Different In Vivo Effects of HIV-1 Immunodominant Epitope-Specific Cytotoxic T Lymphocytes on Selection of Escape Mutant Viruses
Authors :Koizumi, Hirokazu
Hashimoto, Masao
Fujiwara, Mamoru
Murakoshi, Hayato
Chikata, Takayuki
Ali Borghan, Mohamed
Hachiya, Atsuko
Kawashima, Yuka
Takata, Hiroshi
Ueno, Takamasa
Oka, Shinichi
Takiguchi, Masafumi
Issue Date :Jun-2010
Citation jtitle :Journal of Virology
vol. :84
no. :11
start page :5508
end page :5519
Abstract :HIV-1 escape mutants are well known to be selected by immune pressure via HIV-1-specific cytotoxic T lymphocytes (CTLs) and neutralizing antibodies. The ability of the CTLs to suppress HIV-1 replication is assumed to be associated with the selection of escape mutants from the CTLs. Therefore, we first investigated the correlation between the ability of HLA-A*1101-restricted CTLs recognizing immunodominant epitopes in vitro and the selection of escape mutants. The result showed that there was no correlation between the ability of these CTLs to suppress HIV-1 replication in vitro and the appearance of escape mutants. The CTLs that had a strong ability to suppress HIV-1 replication in vitro but failed to select escape mutants expressed a higher level of PD-1 in vivo, whereas those that had a strong ability to suppress HIV-1 replication in vitro and selected escape mutants expressed a low level of PD-1. Ex vivo analysis of these CTLs revealed that the latter CTLs had a significantly stronger ability to recognize the epitope than the former ones. These results suggest that escape mutations are selected by HIV-1-specific CTLs that have a stronger ability to recognize HIV-1 in vivo but not in vitro.
URL :http://jvi.asm.org/cgi/content/abstract/84/11/5508
Type Local :雑誌掲載論文
Publisher :American Society for Microbiology
Rights :© 2010, American Society for Microbiology.
URI :http://hdl.handle.net/2298/17476
Appears in Collections:Journal Article (Center for AIDS Research)
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/17476