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Ｊｏｕｒｎａｌ Ａｒｔｉｃｅｌ （Center for AIDS Research） >
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| Title | : | Different In Vivo Effects of HIV-1 Immunodominant Epitope-Specific Cytotoxic T Lymphocytes on Selection of Escape Mutant Viruses |
| Authors | : | Hirokazu, Koizumi
Masao, Hashimoto
Mamoru, Fujiwara
Hayato, Murakoshi
Takayuki, Chikata
Mohamed, Ali Borghan
Atsuko, Hachiya
Yuka, Kawashima
Hiroshi, Takata
Takamasa, Ueno
Shinichi, Oka
Masafumi, Takiguchi |
| Issue Date | : | Jun-2010 |
| Citation jtitle | : | Journal of Virology |
| vol. | : | 84 |
| no. | : | 11 |
| start page | : | 5508 |
| end page | : | 5519 |
| Abstract | : | HIV-1 escape mutants are well known to be selected by immune pressure via HIV-1-specific cytotoxic T lymphocytes (CTLs) and neutralizing antibodies. The ability of the CTLs to suppress HIV-1 replication is assumed to be associated with the selection of escape mutants from the CTLs. Therefore, we first investigated the correlation between the ability of HLA-A*1101-restricted CTLs recognizing immunodominant epitopes in vitro and the selection of escape mutants. The result showed that there was no correlation between the ability of these CTLs to suppress HIV-1 replication in vitro and the appearance of escape mutants. The CTLs that had a strong ability to suppress HIV-1 replication in vitro but failed to select escape mutants expressed a higher level of PD-1 in vivo, whereas those that had a strong ability to suppress HIV-1 replication in vitro and selected escape mutants expressed a low level of PD-1. Ex vivo analysis of these CTLs revealed that the latter CTLs had a significantly stronger ability to recognize the epitope than the former ones. These results suggest that escape mutations are selected by HIV-1-specific CTLs that have a stronger ability to recognize HIV-1 in vivo but not in vitro. |
| URL | : | http://jvi.asm.org/cgi/content/abstract/84/11/5508 |
| Type Local | : | 雑誌掲載論文 |
| Publisher | : | American Society for Microbiology |
| Rights | : | © 2010, American Society for Microbiology. |
| URI | : | http://hdl.handle.net/2298/17476 |
| Appears in Collections | : | Ｊｏｕｒｎａｌ Ａｒｔｉｃｅｌ （Center for AIDS Research）
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2298/17476
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