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Title :ヘム生合成と鉛貧血
Authors :原田, 幸一
Issue Date :31-Jan-2006
Citation jtitle :熊本大学医学部保健学科紀要
vol. :2
start page :1
end page :6
Abstract :鉛貧血については、鉛により赤血球膜の浸透圧に対する脆弱性が増大し、そのため赤血球が破壊することによる溶血性貧血と、ヘム生合成への鉛の阻害作用による貧血の2つの観点から理解される。ここでは、ヘム生合成に影響する鉛による貧血について考察する。
The nature of lead anemia is still unknown about its mechanism. There are some hypotheses that lead interfere with specific enzymes such as 5-aminolevurinic acid dehydratase, ferrochelatase and reductase participating heme biosynthesis in bodies. It is thought that by the perturbation of lead on the heme pathway 5-aminolevulinic acid and protoporphyrin accumulate in urine and blood, respectively. It is also supposed that lead interfere with intake of iron into the site of heme biosynthesis. The determined values of porphyrins are not only good biological parameters for the effect of lead on heme biosynthesis but also well evaluating the supposed mechanism of lead anemia. The present paper well reviews the point of lead disturbance about heme biosynthesis.
Type Local :紀要論文
ISSN :18807151
Publisher :熊本大学
URI :http://hdl.handle.net/2298/17776
Appears in Collections:Bulletin of Kumamoto University, School of Health Sciences (Medicine)
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/17776