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タイトル :CDKインヒビターによるアポトーシス制御
著者 :梶原, 隆太郎
福重, 翔太
田邊, 香野
乾, 誠司
刊行年月日 :2011-3-23
収録雑誌名 :熊本大学医学部保健学科紀要
巻 :7
開始ページ :1
終了ページ :9
要約(Abstract) :Cell division relies on the activation of cyclins, which bind to cyclin-dependent kinases (CDKs) to induce cell cycle progression towards S phase and later to initiate mitosis. Since uncontrolled cyclin-dependent kinase activity is often the cause of human cancer, their function is tightly regulated by cell-cycle inhibitors such as the p21 and p27 Cip/Kip proteins. Following anti-mitogenic signals or DNA damage, p21 and p27 bind to cyclin-CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest. Interestingly, recent discoveries suggest that p21 and p27 might have new activities that are unrelated to their function as CDK inhibitors. The identification of new targets of Cip/Kip proteins as well as evidence of Cip/Kip cytoplasmic relocalization have revealed unexpected functions of these proteins in the regulation of apoptosis. This article discusses recent insights into this possible additional functions of p21 and p27.
収録種別 :紀要論文
ISSN :18807151
出版社(者) :熊本大学
URI :http://hdl.handle.net/2298/20118
このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/2298/20118