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タイトル :Nerve growth factor, pain, itch and inflammation: lessons from congenital insensitivity to pain with anhidrosis
著者 :Indo, Yasuhiro
刊行年月日 :2010-11
収録雑誌名 :Expert Review of Neurotherapeutics
巻 :10
号 :11
開始ページ :1707
終了ページ :1724
要約(Abstract) :NGF is a well-known neurotrophic factor essential for the survival and maintenance of primary afferent neurons and sympathetic neurons. NGF is also an inflammatory mediator associated with pain and itch. Congenital insensitivity to pain with anhidrosis is a genetic disorder due to loss-of-function mutations in the NTRK1 gene encoding TrkA, a receptor tyrosine kinase for NGF. Since patients with congenital insensitivity to pain with anhidrosis lack NGF-dependent unmyelinated (C-) and thinly myelinated (Aδ-) fibers, and their dermal sweat glands are without innervation, they exhibit no pain, itch, signs of neurogenic inflammation or sympathetic skin responses. Based on the pathophysiology of congenital insensitivity to pain with anhidrosis, this article indicates how NGF-dependent neurons are essential for the establishment of neural networks for interoception and homeostasis, and play crucial roles in brain-immune-endocrine interactions in pain, itch and inflammation. In addition, it refers to involvements of the NGF-TrkA system in various disease states, and potential pharmacological effects when this system is targeted.
URL :http://www.expert-reviews.com/doi/abs/10.1586/ern.10.154
収録種別 :雑誌掲載論文
出版社(者) :Expert Reviews
権利(Rights) :2010 Expert Reviews Ltd,
備考 :Theme: Pain - Review
URI :http://hdl.handle.net/2298/23889
このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/2298/23889