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Title :Nerve growth factor, pain, itch and inflammation: lessons from congenital insensitivity to pain with anhidrosis
Authors :Indo, Yasuhiro
Issue Date :Nov-2010
Citation jtitle :Expert Review of Neurotherapeutics
vol. :10
no. :11
start page :1707
end page :1724
Abstract :NGF is a well-known neurotrophic factor essential for the survival and maintenance of primary afferent neurons and sympathetic neurons. NGF is also an inflammatory mediator associated with pain and itch. Congenital insensitivity to pain with anhidrosis is a genetic disorder due to loss-of-function mutations in the NTRK1 gene encoding TrkA, a receptor tyrosine kinase for NGF. Since patients with congenital insensitivity to pain with anhidrosis lack NGF-dependent unmyelinated (C-) and thinly myelinated (Aδ-) fibers, and their dermal sweat glands are without innervation, they exhibit no pain, itch, signs of neurogenic inflammation or sympathetic skin responses. Based on the pathophysiology of congenital insensitivity to pain with anhidrosis, this article indicates how NGF-dependent neurons are essential for the establishment of neural networks for interoception and homeostasis, and play crucial roles in brain-immune-endocrine interactions in pain, itch and inflammation. In addition, it refers to involvements of the NGF-TrkA system in various disease states, and potential pharmacological effects when this system is targeted.
URL :http://www.expert-reviews.com/doi/abs/10.1586/ern.10.154
Type Local :雑誌掲載論文
Publisher :Expert Reviews
Rights :2010 Expert Reviews Ltd,
Comment :Theme: Pain - Review
URI :http://hdl.handle.net/2298/23889
Appears in Collections:Journal Article (Medicine)
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/23889