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Title :[18F] 酢酸の標識合成と分取精製 (臨床応用への基礎実験)
Authors :宮崎, 吉博
二宮, 賢太郎
竹永, 枝里子
山野, 正起
盛島, 由貴
野守, 裕明
冨吉, 勝美
Issue Date :30-Mar-2012
Citation jtitle :熊本大学医学部保健学科紀要
vol. :8
start page :71
end page :76
Abstract :18F-Acetate (18F-Ace) was synthesized by a simple and quick halogen phase exchange catalysis. solvent extraction method was employed to purify 18F-Ace directly from the reaction vessel. These all simple synthesis and purification method make reactions short and quick so that all synthesis time takes less than 30 minutes. 2- Iodo-acetic ethylester (ICH2COOC2H5) dissolved in anhydrous acetylnirile reacted with 18F-fluorine in Kriptfix-222 and produce 2-18F-acetic ethylester in acetylinitrile. Final product 18F-Ace was obtained by hydrolysis of 2-18F-acetic ethylester in 0.25N NaOH. 18F-Actate radiochemical yield was 48.7% ± 5.2% (n-5). Pyrogen test and sterility check were all negative. With these new simple synthesis and quick purification. 18F-Ace will be more employed to diagnose tumors such as well differentiate one then 18FDG.
Type Local :紀要論文
ISSN :18807151
Publisher :熊本大学
URI :http://hdl.handle.net/2298/24603
Appears in Collections:Bulletin of Kumamoto University, School of Health Sciences (Medicine)
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/24603