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タイトル :Pan-neuronal knockdown of the c-Jun N-terminal Kinase (JNK) results in a reduction in sleep and longevity in Drosophila
著者 :Takahama, Kazuhiro
Tomita, Jun
Ueno, Taro
Yamazaki, Masako
Kume, Shoen
Kume, Kazuhiko
刊行年月日 :2012-1-13
収録雑誌名 :Biochemical and Biophysical Research Communications
巻 :417
号 :2
開始ページ :807
終了ページ :811
要約(Abstract) :Sleep is a unique behavioral state that is conserved between species, and sleep regulation is closely associated to metabolism and aging. The fruit fly, Drosophila melanogaster has been used to study the molecular mechanism underlying these physiological processes. Here we show that the c-Jun N-terminal Kinase (JNK) gene, known as basket (bsk) in Drosophila, functions in neurons to regulate both sleep and longevity in Drosophila. Pan-neuronal knockdown of JNK mRNA expression by RNA interference resulted in a decrease in both sleep and longevity. A heterozygous knockout of JNK showed similar effects, indicating the molecular specificity. The JNK knockdown showed a normal arousal threshold and sleep rebound, suggesting that the basic sleep mechanism was not affected. JNK is known to be involved in the insulin pathway, which regulates metabolism and longevity. A JNK knockdown in insulin-producing neurons in the pars intercerebralis had slight effects on sleep. However, knocking down JNK in the mushroom body had a significant effect on sleep. These data suggest a unique sleep regulating pathway for JNK.
URL :http://www.sciencedirect.com/science/article/pii/S0006291X11022492
収録種別 :雑誌掲載論文
ISSN :0006291X
出版社(者) :Elsevier
Academic Press Inc
権利(Rights) :© 2012 Elsevier
URI :http://hdl.handle.net/2298/24801
このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/2298/24801