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Title :Genetic background of resistance to cadmium-induced testicular toxicity in inbred Wistar-Imamichi rats
Authors :Shimada, Hideaki
Hata, Iori
Hashiguchi, Takashi
Imamura, Yorishige
Issue Date :Oct-2011
Citation jtitle :Archives of Toxicology
vol. :85
no. :10
start page :1195
end page :1199
Abstract :We have previously reported that inbred Wistar-Imamichi (WI) rats are highly resistant to cadmium (Cd)-induced testicular toxicity compared to inbred Fischer 344 (F344) rats. The present study was to elucidate the genetic background of resistance to Cd-induced testicular toxicity in WI rats. The genetic analysis of susceptibility to Cd-induced testicular toxicity was conducted, by using Cd-resistant WI and Cd-sensitive F344 strains as the parental rats, and by using the testicular hemoglobin level as the indicator. In the frequency distribution of testicular hemoglobin levels in parental, first filial (F1) and second filial (F2) rats treated with Cd at a dose of 2.0 mg/kg, F1 rats had testicular hemoglobin levels intermediate to WI and F344 rats, and F2 rats segregated into three groups of low, intermediate and high phenotypes at the expected ratio. Furthermore, the backcross progeny between WI and F1 or between F344 and F1 segregated into two groups with the expected ratio. Based on a simple Mendelian genetic analysis, these segregation patterns lead us to conclude that two co-dominant alleles at a gene locus are responsible for the susceptibility to Cd-induced testicular toxicity in rats. This is the first report for the genetic analysis of susceptibility to Cd-induced testicular toxicity in inbred rat strains.
URL :http://www.springerlink.com/content/p412h850t3pw0v55/?MUD=MP
Type Local :雑誌掲載論文
ISSN :0340-5761
Publisher :Springer
Rights :© 2011 Springer
URI :http://hdl.handle.net/2298/25965
Appears in Collections:Journal Article (Education)
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/25965