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0031-6903v133_1103-1111.pdf543KbAdobe PDF見る/開く
タイトル :エイズウイルスタンパク質の分子機能に関する研究
著者 :藤田, 美歌子
刊行年月日 :2013-10
収録雑誌名 :藥學雑誌
巻 :133
号 :10
開始ページ :1103
終了ページ :1111
要約(Abstract) :Human immunodeficiency virus (HIV) has no more than nine genes expressing approximately twenty proteins. When T lymphocytes and macrophages in a body are infected with HIV, these proteins work in turn at specific time and location, causing acquired immunodeficiency syndrome (AIDS), a disease yet to be overcome. Since the elucidation of molecular mechanism of HIV proteins should lead to remedy of AIDS, the author has been engaged in the study of HIV protein in the past decade. Described herein are viral protein X (Vpx), uniquely found in HIV-2,and its homologous protein Vpr found both in HIV-1 and -2. We found that Vpx enhances genome nuclear import in T lymphocytes, and is critical for reverse transcription of viral RNA in macrophages. This finding on the function in macrophages corrected long-term misleading belief. Furthermore, functional region mapping of Vpx was performed. In 2011, the protein SAMHD1 was identified as the host restriction factor counteracted by Vpx, by foreign researchers. After that, our independent study demonstrated the presence of SAMHD1-independent functions of Vpx in T cells, in addition to its SAMHD1-dependent functions in macrophages. Another topic of this review is Gag protein. Recently, it has reported by oversea researchers that PI(4,5)P2(one of phosphoinositide) regulates Pr55^<Gag> localization and assembly. In this study, we determined the binding affinity between N-terminal MA domain of Pr55^<Gag> and various phosphoinositide derivatives using surface plasmon resonance. The results suggested that both negatively charged inositol phosphates and hydrophobic acyl chain are required for the MA binding.
収録種別 :雑誌掲載論文
ISSN :00316903
出版社(者) :日本薬学会
権利(Rights) :© 2013 The Pharmaceutical Society of Japan
URI :http://hdl.handle.net/2298/31761
出現コレクション:発表論文(薬学系)
このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/2298/31761

 

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