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Title :全身性アミロイドーシス検索薬125I-EISBの研究 : 最適反応時間および安定性の検討
Authors :柏, 昂希
副島, 彩花
松永, 浩文
山下, 太郎
冨吉, 勝美
Issue Date :31-Mar-2018
Citation jtitle :熊本大学医学部保健学科紀要
vol. :14
start page :42
end page :47
Abstract :1-(2-mestyl-ethoxy) -2,5bis (styryl) benzene (EMSB) is newly synthesized and reacted with 125I with Kripffix222 to obtain 1- (125I-ethoxy) -2,5bis (styryl) benzene (125I-EISB) which is a new amyloid imaging probe that can image amyloid by Single Photon Emission Computed Tomography (SPECT). The purpose of study is to determine the optimal synthesis time and clarify stability of 125I-EISB in saline and human serum, respectively. We synthesized 125I-EISB and injected 125I-EISB into saline and human serum. We used high performance liquid chromatography (HPLC) to acquire radiochemical purity of 125I-EISB. We assess changes of radiochemical purity of 125I-EISB over time. As a result, high radioactive purity 95.88±3.19% was obtained in 10 minutes by our synthesis and the radiochemical purity was 97.83±1.40% (n=6) applying our purification system. Radiochemical purity 24 hours later was 94.01±2.09% after injecting in saline. That was 94.23±1.20% after injecting in human serum. From these results, optimal synthesis time was determined 10 minutes and radiochemical purity of 125I-EISB was stably maintained in saline and human serum, respectively.
Type Local :紀要論文
Publisher :熊本大学
Comment :【著者所属】柏昂希:熊本大学大学院保健学教育部 / 副島彩花:熊本大学医学部保健学科 / 松永浩文:熊本大学大学院薬学教育部 / 山下太郎:熊本大学医学部付属病院 / 冨吉勝美:熊本大学大学院生命科学研究部
URI :http://hdl.handle.net/2298/39288
Appears in Collections:Bulletin of Kumamoto University, School of Health Sciences (Medicine)
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/39288