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タイトル :NGF-dependent neurons and neurobiology of emotions and feelings : Lessons from congenital insensitivity to pain with anhidrosis
著者 :Indo, Yasuhiro
刊行年月日 :2018-4
収録雑誌名 :Neuroscience & Biobehavioral Reviews
巻 :87
開始ページ :1
終了ページ :16
要約(Abstract) :NGF is a well-studied neurotrophic factor, and TrkA is a receptor tyrosine kinase for NGF. The NGF-TrkA system supports the survival and maintenance of NGF-dependent neurons during development. Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder due to loss-of-function mutations in the NTRKI gene encoding TrkA. Individuals with CIPA lack NGF-dependent neurons, including NGF-dependent primary afferents and sympathetic postganglionic neurons, in otherwise intact systems. Thus, the pathophysiology of CIPA can provide intriguing findings to elucidate the unique functions that NGF-dependent neurons serve in humans, which might be difficult to evaluate in animal studies. Preceding studies have shown that the NGF-TrkA system plays critical roles in pain, itching and inflammation. This review focuses on the clinical and neurobiogical aspects of CIPA and explains that NGF-dependent neurons in the peripheral nervous system play pivotal roles in interoception and homeostasis of our body, as well as in the stress response. Furthermore, these NGF-dependent neurons are likely requisite for neurobiological processes of 'emotions and feelings' in our species.
URL :https://www.sciencedirect.com/science/article/pii/S0149763417307121?via%3Dihub
収録種別 :雑誌掲載論文
ISSN :01497634
出版社(者) :Elsevier
備考 :Gold Open Access
URI :http://hdl.handle.net/2298/39781
出現コレクション:発表論文(医学系)
このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/2298/39781

 

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