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Title :NGF-dependent neurons and neurobiology of emotions and feelings : Lessons from congenital insensitivity to pain with anhidrosis
Authors :Indo, Yasuhiro
Issue Date :Apr-2018
Citation jtitle :Neuroscience & Biobehavioral Reviews
vol. :87
start page :1
end page :16
Abstract :NGF is a well-studied neurotrophic factor, and TrkA is a receptor tyrosine kinase for NGF. The NGF-TrkA system supports the survival and maintenance of NGF-dependent neurons during development. Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder due to loss-of-function mutations in the NTRKI gene encoding TrkA. Individuals with CIPA lack NGF-dependent neurons, including NGF-dependent primary afferents and sympathetic postganglionic neurons, in otherwise intact systems. Thus, the pathophysiology of CIPA can provide intriguing findings to elucidate the unique functions that NGF-dependent neurons serve in humans, which might be difficult to evaluate in animal studies. Preceding studies have shown that the NGF-TrkA system plays critical roles in pain, itching and inflammation. This review focuses on the clinical and neurobiogical aspects of CIPA and explains that NGF-dependent neurons in the peripheral nervous system play pivotal roles in interoception and homeostasis of our body, as well as in the stress response. Furthermore, these NGF-dependent neurons are likely requisite for neurobiological processes of 'emotions and feelings' in our species.
URL :https://www.sciencedirect.com/science/article/pii/S0149763417307121?via%3Dihub
Type Local :雑誌掲載論文
ISSN :01497634
Publisher :Elsevier
Comment :Gold Open Access
URI :http://hdl.handle.net/2298/39781
Appears in Collections:Journal Article (Medicine)
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/39781