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タイトル :The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections
著者 :Matsuoka, Masao
Yasuma-Mitobe, Keiko
刊行年月日 :2018-11-27
収録雑誌名 :Frontiers in Immunology
巻 :9
号 :2755
開始ページ :1
終了ページ :8
要約(Abstract) :Costimulatory and coinhibitory receptors play a key role in regulating immune responses to infection and cancer. Coinhibitory receptors include programmed cell death 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), and T cell immunoglobulin and ITIM domain (TIGIT), which suppress immune responses. Coinhibitory receptors are highly expressed on exhausted virus-specific T cells, indicating that viruses evade host immune responses through enhanced expression of these molecules. Human retroviruses, human immunodeficiency virus (HIV) and human T-cell leukemia virus type 1 (HTLV-1), infect T cells, macrophages and dendritic cells. Therefore, one needs to consider the effects of coinhibitory receptors on both uninfected effector T cells and infected target cells. Coinhibitory receptors are implicated not only in the suppression of immune responses to viruses by inhibition of effector T cells, but also in the persistence of infected cells in vivo. Here we review recent studies on coinhibitory receptors and their roles in retroviral infections such as HIV and HTLV-1.
URL :https://www.frontiersin.org/articles/10.3389/fimmu.2018.02755/full
収録種別 :雑誌掲載論文
ISSN :16643224
出版社(者) :Frontiers Media
URI :http://hdl.handle.net/2298/41363
このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/2298/41363