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Title :高度遮蔽型新規2-アミノチオール誘導体を用いた不斉制御系の開発
Authors :德田, 亮
Issue Date :27-Mar-2007
Abstract :We previously developed some chiral “roofed” 2-thiazolidinones, which were conformationally rigid and sterically bulky, by the thermal [4+2] cycloaddition of a simple 5-membered heterocycle, 2-thiazolone, to cyclic dienes followed by optical resolution. These compounds have proven to be excellent chiral auxiliaries for asymmetric C-C bond formations, including α-alkylations of carbonyl compounds and β-conjugate additions. The excellent stereoselectivities obtained in these reactions prompted us to apply this unique skeleton to the preparation of a new type of chiral “roofed” 2-thiazoline ligands and chiral “roofed” 2-iminosulfide ligands and to test them for catalytic asymmetric reactions as chiral ligands.
Type Local :博士論文
Publisher :熊本大学
URI :http://hdl.handle.net/2298/8697
Appears in Collections:Doctor of Pharmacy
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/8697