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Title :水チャンネル aquaporin の機能調節機構に関する研究
Authors :長井, 一史
Issue Date :27-Mar-2007
Abstract :Aquaporins (AQPs) are a family of water channel proteins that allow the rapid movement of water in response to osmotic gradients. To date, 13 homologous members of the AQP family have been identified and they are expressed in various organs. Phenotype studies of transgenic AQP knockout mouse models have demonstrated essential roles for AQP in mammalian physiology and pathophysiology. For instance, mice lacking AQPs that are expressed in kidney are polyuric because they were unable to concentrate their urine. AQP5 is expressed in exocrine glands and alveolar type I cells. AQP5-deficient mice exhibit reduced secretion of saliva, sweat and airway fluids. AQP4 is expressed in astrocyte endfeet in the brain. AQP4-deficient mice show reduced traumatic brain injury-induced cerebral edema. Consequently, these studies have been suggested that AQPs are potential targets for new diuretic reagents and novel drugs for disorders that involve water movement, such as brain edema and abnormal airway secretion. However, the functional regulation of AQP has not been fully understood and the clinical modulators of AQP have not been identified. Therefore, in this study, to find new modulators of AQPs, I examined the effects of kampo medicine, various metals and nitric oxide on AQP activity.
Type Local :博士論文
Publisher :熊本大学
URI :http://hdl.handle.net/2298/8701
Appears in Collections:Doctor of Pharmacy
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/8701