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Title :小胞体シャペロンによるアミロイドβ産生抑制
Authors :星野, 竜也
Issue Date :27-Mar-2007
Abstract :Amyloid-β peptides (Aβgenerated by proteolysis of β-amyloid precursor protein (APP), play an important role in the pathogenesis of Alzheimer’s disease. Endoplasmic reticulum (ER) chaperones, such as glucose-regulated protein (GRP)78, make a major contribution to protein quality control in the ER. Here I examined the effect of over-expression of various ER chaperones on the production of Aβin cultured cells, which produce a mutant type of APP (APPsw).
Type Local :博士論文
Publisher :熊本大学
URI :http://hdl.handle.net/2298/8728
Appears in Collections:Doctor of Pharmacy
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/8728