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Title :小腸におけるエステラーゼ発現レベルと代謝能の定量的解析に関する研究
Authors :眞﨑, 賢治
Issue Date :27-Mar-2007
Abstract :These findings indicate that the intestine markedly contributes to first-pass hydrolysis of prodrug and CESs mainly involves in the hydrolysis in the jejunum and ileum as well as liver. The expression level of CES isozymes is slightly varied according to age and intestinal region. Design of an orally administrated prodrug will be successful by controlling the CES mediated intestinal hydrolysis.
Type Local :博士論文
Publisher :熊本大学
URI :http://hdl.handle.net/2298/8732
Appears in Collections:Doctor of Pharmacy
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/8732