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Title :非莢膜保有型インフルエンザ菌による TLR7 発現制御および肺炎球菌による炎症性メディエーターの発現制御に関する研究 : 細胞内シグナル伝達抑制因子としての脱ユビキチン化酵素 CYLD の関与
Authors :古賀, 友紹
Issue Date :25-Mar-2008
Abstract :Infectious diseases such as pneumonia and tuberculosis that historically have killed millions of people were almost conquered in the middle of 20th century by the discovery of antibiotics, and development of chemotherapy. Despite these progresses, because of the inappropriate antibiotic use in the clinic, antibiotic-resistant strains of various bacteria have dramatically increased over the past decade. Moreover, the emergence of new pathogens and the resurgence of old ones have also increased. Therefore, development of alternative therapeutic strategies targeting host response is urgently needed for the treatment of various infections based on full understanding of the molecular pathogenesis of each infection. In the present study, I investigated the molecular mechanisms underlying nontypeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae (S. pneumoniae)-induced host defense responses. NTHi and S. pneumoniae are important human pathogens causing inflammatory diseases including otitis media, the exacerbation of chronic obstructive pulmonary disease (COPD), and pneumonia.
Type Local :博士論文
Publisher :熊本大学
URI :http://hdl.handle.net/2298/9378
Appears in Collections:Doctor of Pharmacy
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/9378