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Title :ホスファチジン酸による CFTR の細胞内輸送制御機構および CFTR 機能破綻により生じる掻痒病態発症機構の解明
Authors :橋本, 泰明
Issue Date :25-Mar-2008
Abstract :The cystic fibrosis transmembrane conductance regulator (CFTR) in which mutation is the cause of cystic fibrosis (CF) is a polytopic integral membrane protein that mediates transepithelial chloride transport across epithelial cells in airways, pancreas, intestines and sweat glands. In addition, CFTR also regulates other various molecules (ion channels and receptors) such as ENaC by forming multimolecular complex called “Transportsome”. Therefore, CFTR molecule is an extremely important molecule for the maintenance of the living body homeostasis and plays a role as universal regulator of a variety of cellular and membrane functions. Because CFTR dysfunction causes various abnormalities in the cell, resulting in the lethal disease such as CF, it is necessary to investigate CFTR regulation and function in health and disease for CF treatment as well as establishing treatment strategy for disease caused by dysfunction of CFTR or its-interacting molecule. In this study, to understand the biological phenomena that originated from CFTR dysfunction, I tried to elucidate the molecular mechanisms of intracellular trafficking of CFTR and a novel biological phenomenon caused by CFTR dysfunction.
Type Local :博士論文
Publisher :熊本大学
URI :http://hdl.handle.net/2298/9382
Appears in Collections:Doctor of Pharmacy
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/9382