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Title :NSAIDs 潰瘍における Heme Oxygenase-1 の役割
Authors :油谷, 真由子
Issue Date :25-Mar-2008
Abstract :Gastric mucosal cell death by non-steroidal anti-inflammatory drugs (NSAIDs) is suggested to be involved in NSAID-induced gastric lesions. Therefore, cellular factors that suppress this cell death are important for protection of the gastric mucosa from NSAIDs. Heme oxygenase-1 (HO-1) is up-regulated by various stressors and protects cells against stressors. Here, we have examined up-regulation of HO-1 by NSAIDs and the contribution of HO-1 to the protection of gastric mucosal cells against NSAIDs both in vitro and in vivo. In cultured gastric mucosal cells, all NSAIDs tested up-regulated HO-1. This is the first report showing the protective role of HO-1 against irritant-induced gastric lesions.
Type Local :博士論文
Publisher :熊本大学
URI :http://hdl.handle.net/2298/9428
Appears in Collections:Doctor of Pharmacy
Please use this identifier to cite or link to this item: http://hdl.handle.net/2298/9428