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|Title ||:||個別化医療の実現に向けた薬理遺伝学的検討 : 抗てんかん薬治療と気道障害予防|
|Authors ||:||瀨尾, 享志|
|Issue Date ||:||25-Mar-2008 |
|Abstract ||:||The field of pharmacogenetics has now celebrated its 50th anniversary. Although science has
delivered an impressive amount of information during those years, the field of
pharmacogenetics/genomics has suffered due to a lack of sufficient integration into clinical practice.
Indeed, commercially available pharmacogenomic tests have been approved by the US Food and
Drug Administration (FDA) in recent years, but their application in patient care remains very
limited. One reason for this is a shortage of clinical evidence regarding the direct impact of
pharmacogenetics/genomics on healthcare.
Therefore, this study demonstrated the clinical impact of genetic polymorphisms on both
antiepileptic drug (AED) therapy and the susceptibility to airway injury.
Pharmacogenomics promises the possibility of performing more personalized medicine in
conjunction with individualized health promotion in near future. However, several challenges
remain for clinical pharmacologist in order to effectively bring the field of pharmacogenomics into
the daily clinical practice of medicine.|
|Type Local ||:||博士論文|
|Appears in Collections||:||Doctor of Pharmacy|
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