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|Title ||:||炎症性腸疾患に対する HSF1、及び HSP70 の保護的役割|
|Authors ||:||田中, 健一郎|
|Issue Date ||:||25-Mar-2008 |
|Abstract ||:||Inflammatory bowel disease (IBD) involves infiltration of leukocytes into intestinal
tissue, resulting in intestinal damage induced by reactive oxygen species (ROS).
Pro-inflammatory cytokines and cell adhesion molecules (CAMs) play important roles
in this infiltration of leukocytes. The roles of heat shock factor 1 (HSF1) and heat
shock proteins (HSPs) in development of IBD are unclear. In this study, we have
examined the roles of HSF1 and HSPs in an animal model of IBD, dextran sulfate
sodium (DSS)-induced colitis.
This study provides the first genetic
evidence that HSF1 and HSP70 play a role in protecting against DSS-induced colitis.
Furthermore, this protective role seems to involve various mechanisms, such as
suppression of expression of pro-inflammatory cytokines and CAMs, and ROS-induced
|Type Local ||:||博士論文|
|Appears in Collections||:||Doctor of Pharmacy|
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